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Article

Purifying selection shapes the coincident SNP distribution of primate coding sequences.

Scientific reports - 3 Jun 2016

Chen Chia-Ying, Hung Li-Yuan, Wu Chan-Shuo, Chuang Trees-Juen

Abstract excerpt

Genome-wide analysis has observed an excess of coincident single nucleotide polymorphisms (coSNPs) at human-chimpanzee orthologous positions, and suggested that this is due to cryptic variation in the mutation rate. While this phenomenon primarily corresponds with non-coding coSNPs, the situation in coding sequences remains unclear. Here we calculate the observed-to-expected ratio of coSNPs (coSNPO/E) to estimate...

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Share to Databases, Genetic
Share to Evolution, Molecular
Share to Mutation Rate

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Polymorphism, Single Nucleotide

Share to Selection, Genetic

Share to Sequence Analysis, DNA

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Identifiers

PMID: 27255481
DOI: 10.1038/srep27272
PMCID: PMC4891680

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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