Article
The genomic distribution and local context of coincident SNPs in human and chimpanzee.
Genome biology and evolution - 1 Jan 2010
Hodgkinson Alan, Eyre-Walker Adam
Abstract excerpt
We have previously shown that there is an excess of sites that are polymorphic at orthologous positions in humans and chimpanzees and that this is most likely due to cryptic variation in the mutation rate. We showed that this might be a consequence of complex context effects since we found significant heterogeneity in triplet frequencies around coincident single nucleotide polymorphism (SNP) sites. Here, we show...
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