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CD44 Splice Variant v8-10 as a Marker of Serous Ovarian Cancer Prognosis

2 Jun 2016

Abstract excerpt

CD44 is a transmembrane hyaluronic acid receptor gene that encodes over 100 different tissue-specific protein isoforms. The most ubiquitous, CD44 standard, has been used as a cancer stem cell marker in ovarian and other cancers. Expression of the epithelial CD44 variant containing exons v8-10 (CD44v8-10) has been associated with more chemoresistant and metastatic tumors in gastrointestinal and breast cancers, but...

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PMID: 27253518
DOI: 10.1371/journal.pone.0156595

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