Article
Nuclear p16INK4a expression predicts enhanced radiation response in head and neck cancers.
Oncotarget - 21 Jun 2016
Dok Rüveyda, Abbasi Asbagh Layka, Van Limbergen Evert Jan, Sablina Anna, Nuyts Sandra
Abstract excerpt
Immunohistochemistry analysis of p16INK4a in head and neck squamous cell carcinomas (HNSCC) tumor samples revealed that 28% of tumors showed nuclear/cytoplasmic p16INK4a localization, while 37% of tumors had cytoplasmic p16INK4a. Our previous study showed that p16INK4a inhibits the DNA repair response independently of its function in the cell cycle, suggesting that p16INK4a subcellular localization should be...
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