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Article

Whole-exome sequencing of a family with local anesthetic resistance.

Minerva anestesiologica - 1 Oct 2016

Clendenen Nathan, Cannon Ashley D, Porter Steven, Robards Christopher B, Parker Alexander S, Clendenen Steven R

Abstract excerpt

BACKGROUND: Local anesthetics (LA) work by blocking sodium conductance through voltage-gated sodium channels. Complete local anesthetic resistance is infrequent, and the cause is unknown. Genetic variation in sodium channels is a potential mechanism for local anesthetic resistance. A patient with a history of inadequate loss of sensation following LA administration underwent an ultrasound-guided brachial plexus...

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PMID: 27243970

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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