Article
Host protein Snapin interacts with human cytomegalovirus pUL130 and affects viral DNA replication.
Journal of biosciences - 1 Jun 2016
Wang Guili, Ren Gaowei, Cui Xin, Lu Zhitao, Ma Yanpin, Qi Ying, Huang Yujing, Liu Zhongyang, Sun Zhengrong, Ruan Qiang
Abstract excerpt
The interplay between the host and Human cytomegalovirus (HCMV) plays a pivotal role in the outcome of an infection. HCMV growth in endothelial and epithelial cells requires expression of viral proteins UL128, UL130, and UL131 proteins (UL128-131), of which UL130 is the largest gene and the only one that is not interrupted by introns.Mutation of the C terminus of the UL130 protein causes reduced tropism of...
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