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The Human Cytomegalovirus Gene UL79 Is Required for the Accumulation of Late Viral Transcripts

4 Mar 2011

Abstract excerpt

In this study, we adopted a conditional protein genetic approach to characterize the role of the human cytomegalovirus (HCMV) gene UL79 during virus infection. We constructed ADddUL79, a recombinant HCMV in which the annotated UL79 open reading frame (ORF) was tagged with the destabilization domain of a highly unstable variant of the human FKBP12 protein (ddFKBP). The ddFKBP domain targets the tagged protein for...

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PMID: 21367901
DOI: 10.1128/jvi.02344-10

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