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Article

What is the biological reality of gene-environment interaction estimates? An assessment of bias in developmental models.

Journal of child psychology and psychiatry, and allied disciplines - 1 Nov 2016

Moore Sarah R, Thoemmes Felix

Abstract excerpt

BACKGROUND: Standard models used to test gene-environment interaction (G × E) hypotheses make the causal assumption that there are no unobserved variables that could be biasing the interaction estimate. Whether this assumption can be met in nonexperimental studies is unclear because the interactive biological pathways from genetic polymorphisms and environments to behavior, and the confounders that can be...

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PMID: 27240973
DOI: 10.1111/jcpp.12579

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