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Increase of Positive Net Charge and Conformational Rigidity Enhances the Efficacy of d-Enantiomeric Peptides Designed to Eliminate Cytotoxic Aβ Species.

ACS chemical neuroscience - 17 Aug 2016

Ziehm Tamar, Brener Oleksandr, van Groen Thomas, Kadish Inga, Frenzel Daniel, Tusche Markus, Kutzsche Janine, Reiß Kerstin, Gremer Lothar, Nagel-Steger Luitgard, Willbold Dieter

Abstract excerpt

Alzheimer's disease (AD) is a neurodegenerative disorder and the most common type of dementia. Until now, there is no curative therapy available. Previously, we selected the amyloid-beta (Aβ) targeting peptide D3 consisting of 12 d-enantiomeric amino acid residues by mirror image phage display as a potential drug candidate for the treatment of AD. In the current approach, we investigated the optimization...

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PMID: 27240424
DOI: 10.1021/acschemneuro.6b00047

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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