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Article

Aβ oligomer eliminating compounds interfere successfully with pEAβ(3-42) induced motor neurodegenerative phenotype in transgenic mice.

Neuropeptides - 1 Feb 2018

Dunkelmann Tina, Teichmann Kerstin, Ziehm Tamar, Schemmert Sarah, Frenzel Daniel, Tusche Markus, Dammers Christina, Jürgens Dagmar, Langen Karl-Josef, Demuth Hans-Ulrich, Shah Nadim Jon, Kutzsche Janine, Willuweit Antje, Willbold Dieter

Abstract excerpt

Currently, there are no causative or disease modifying treatments available for Alzheimer's disease (AD). Previously, it has been shown that D3, a small, fully d-enantiomeric peptide is able to eliminate low molecular weight Aβ oligomers in vitro, enhance cognition and reduce plaque load in AD transgenic mice. To further characterise the therapeutic potential of D3 towards N-terminally truncated and...

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Identifiers

PMID: 29273382
DOI: 10.1016/j.npep.2017.11.011

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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