Article
Oncogene mutation profiling reveals poor prognosis associated with FGFR1/3 mutation in liposarcoma.
Human pathology - 1 Sept 2016
Li Chengfang, Shen Yaoyuan, Ren Yan, Liu Wei, Li Man, Liang Weihua, Liu Chunxia, Li Feng
Abstract excerpt
Liposarcoma (LPS) is one of the most prevalent soft tissue sarcomas. LPS shows a poor response to radiation and chemotherapy. The causes of death in patients with LPS include locally recurrent and metastatic disease. We sought to examine novel gene mutations and pathways in primary and matched recurrent LPSs to identify potential therapeutic targets. We conducted a high-throughput analysis of 238 known mutations...
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