Article
Sustained efficacy of artesunate-sulfadoxine-pyrimethamine against Plasmodium falciparum in Yemen and a renewed call for an adjunct single dose primaquine to clear gametocytes.
Malaria journal - 27 May 2016
Atroosh Wahib M, Al-Mekhlafi Hesham M, Snounou Georges, Al-Jasari Adel, Sady Hany, Nasr Nabil A, Lau Yee-Ling, Surin Johari
Abstract excerpt
BACKGROUND: In Yemen, artesunate plus sulfadoxine-pyrimethamine (AS + SP) has been used as first-line treatment for uncomplicated falciparum malaria, which accounts for about 99 % of malaria cases. There is evidence that resistance to SP is increasing, with potential negative impact on efficacy, and in particular on curbing transmission. This study aims: (a) to evaluate the therapeutic efficacy of AS + SP...
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