Isocitrate Dehydrogenase Mutations Confer Dasatinib Hypersensitivity and SRC Dependence in Intrahepatic Cholangiocarcinoma.

doi:10.1158/2159-8290.CD-15-1442

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Article

Isocitrate Dehydrogenase Mutations Confer Dasatinib Hypersensitivity and SRC Dependence in Intrahepatic Cholangiocarcinoma.

Cancer discovery - 1 Jul 2016

Saha Supriya K, Gordan John D, Kleinstiver Benjamin P, Vu Phuong, Najem Mortada S, Yeo Jia-Chi, Shi Lei, Kato Yasutaka, Levin Rebecca S, Webber James T, Damon Leah J, Egan Regina K, Greninger Patricia, McDermott Ultan, Garnett Mathew J, Jenkins Roger L, Rieger-Christ Kimberly M, Sullivan Travis B, Hezel Aram F, Liss Andrew S, Mizukami Yusuke, Goyal Lipika, Ferrone Cristina R, Zhu Andrew X, Joung J Keith, Shokat Kevan M, Benes Cyril H, Bardeesy Nabeel

Abstract excerpt

UNLABELLED: Intrahepatic cholangiocarcinoma (ICC) is an aggressive liver bile duct malignancy exhibiting frequent isocitrate dehydrogenase (IDH1/IDH2) mutations. Through a high-throughput drug screen of a large panel of cancer cell lines, including 17 biliary tract cancers, we found that IDH mutant (IDHm) ICC cells demonstrate a striking response to the multikinase inhibitor dasatinib, with the highest...

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Identifiers

PMID: 27231123
DOI: 10.1158/2159-8290.CD-15-1442
PMCID: PMC5458737

Genes

SRC
IDH1
IDH2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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