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Article

GRIN2A polymorphisms and expression levels are associated with lead-induced neurotoxicity.

Toxicology and industrial health - 1 Apr 2017

Wu Yu, Wang Yiqing, Wang Miaomiao, Sun Na, Li Chunping

Abstract excerpt

Lead acts as an antagonist of the N-methyl-d-aspartate receptor (NMDAR). GRIN2A encodes an important subunit of NMDARs and may be a critical factor in the mechanism of lead neurotoxicity. Changes in GRIN2A expression levels or gene variants may be mechanisms of lead-induced neurotoxicity. In this study, we hypothesized that GRIN2A might contribute to lead-induced neurotoxicity. A preliminary HEK293 cell...

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PMID: 27230353
DOI: 10.1177/0748233716647636

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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