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Article

Activation of the antiviral prodrug oseltamivir is impaired by two newly identified carboxylesterase 1 variants.

Drug metabolism and disposition: the biological fate of chemicals - 1 Feb 2009

Zhu Hao-Jie, Markowitz John S

Abstract excerpt

Oseltamivir phosphate is an ethyl ester prodrug widely used in the treatment and prevention of both Influenzavirus A and B infections. The conversion of oseltamivir to its active metabolite oseltamivir carboxylate is dependent on ester hydrolysis mediated by carboxylesterase 1 (CES1). We recently identified two functional CES1 variants p.Gly143Glu and p.Asp260fs in a research subject who displayed significant...

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Source

Identifiers

PMID: 19022936
DOI: 10.1124/dmd.108.024943

Genes

CES1

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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