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Article

Analysis of receptor tyrosine kinase genetics identifies two novel risk loci in GAS6 and PROS1 in Behçet's disease.

Scientific reports - 25 May 2016

Qin Jieying, Li Lin, Zhang Donglei, Yu Hongsong, Tan Handan, Zhang Jun, Deng Bolin, Kijlstra Aize, Yang Peizeng

Abstract excerpt

The TAM kinase (Tyro3, Axl, Mer) and its two ligands (Gas6 and protein S) have been shown to play an important regulatory role in the innate immune response. The present study aimed to investigate whether the tag single-nucleotide polymorphisms (tag SNPs) of these 5 protein-coding genes are associated with Behçet's disease (BD). A two-stage association study was performed in a total of 907 BD patients and 1780...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Intercellular Signaling Peptides and Proteins

Share to Polymorphism, Restriction Fragment Length

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Share to Receptor Protein-Tyrosine Kinases

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Source

Open in PubMed Open full text

Identifiers

PMID: 27222359
DOI: 10.1038/srep26662
PMCID: PMC4879572

Genes

GAS6
PROS1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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