Article
Variant Alleles in XRCC1 Arg194Trp and Arg399Gln Polymorphisms Increase Risk of Gastrointestinal Cancer in Sabah, North Borneo.
Asian Pacific journal of cancer prevention : APJCP - 1 Jan 2016
Halim Noor Hanis Abu, Chong Eric Tzyy Jiann, Goh Lucky Poh Wah, Chuah Jitt Aun, See Edwin Un Hean, Chua Kek Heng, Lee Ping-Chin
Abstract excerpt
BACKGROUND: The XRCC1 protein facilitates various DNA repair pathways; single-nucleotide polymorphisms (SNPs) in this gene are associated with a risk of gastrointestinal cancer (GIC) with inconsistent results, but no data have been previously reported for the Sabah, North Borneo, population. We accordingly investigated the XRCC1 Arg194Trp and Arg399Gln SNPs in terms of GIC risk in Sabah. MATERIALS AND METHODS: We...
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