Article
Screening for Lynch Syndrome in Young Colorectal Cancer Patients from Saudi Arabia Using Microsatellite Instability as the Initial Test.
Asian Pacific journal of cancer prevention : APJCP - 1 Jan 2016
Alqahtani Masood, Grieu Fabienne, Carrello Amerigo, Amanuel Benhur, Mashour Miral, Alattas Rabab, Alsaleh Khalid, Alsheikh Abdulmalik, Alqahtani Sarah, Iacopetta Barry
Abstract excerpt
BACKGROUND: Lynch Syndrome (LS) is a familial cancer condition caused by germline mutations in DNA mismatch repair genes. Individuals with LS have a greatly increased risk of developing colorectal cancer (CRC) and it is therefore important to identify mutation carriers so they can undergo regular surveillance. Tumor DNA from LS patients characteristically shows microsatellite instability (MSI). Our aim here was...
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