Article
The Tumor-Associated Glycosyltransferase ST6Gal-I Regulates Stem Cell Transcription Factors and Confers a Cancer Stem Cell Phenotype.
Cancer research - 1 Jul 2016
Schultz Matthew J, Holdbrooks Andrew T, Chakraborty Asmi, Grizzle William E, Landen Charles N, Buchsbaum Donald J, Conner Michael G, Arend Rebecca C, Yoon Karina J, Klug Christopher A, Bullard Daniel C, Kesterson Robert A, Oliver Patsy G, O'Connor Amber K, Yoder Bradley K, Bellis Susan L
Abstract excerpt
The glycosyltransferase ST6Gal-I, which adds α2-6-linked sialic acids to substrate glycoproteins, has been implicated in carcinogenesis; however, the nature of its pathogenic role remains poorly understood. Here we show that ST6Gal-I is upregulated in ovarian and pancreatic carcinomas, enriched in metastatic tumors, and associated with reduced patient survival. Notably, ST6Gal-I upregulation in cancer cells...
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