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Article

Efflux-pump-derived multiple drug resistance to ethambutol monotherapy in Mycobacterium tuberculosis and the pharmacokinetics and pharmacodynamics of ethambutol.

The Journal of infectious diseases - 15 Apr 2010

Srivastava Shashikant, Musuka Sandirai, Sherman Carleton, Meek Claudia, Leff Richard, Gumbo Tawanda

Abstract excerpt

BACKGROUND: Ethambutol is used for the treatment of tuberculosis in cases where there is isoniazid resistance. We examined the emergence of drug resistance to ethambutol monotherapy in pharmacokinetic-pharmacodynamic studies of a hollow-fiber system. METHODS: Dose-effect and dose-scheduling studies were performed with ethambutol and log-phase growth Mycobacterium tuberculosis to identify exposures and schedules...

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Identifiers

PMID: 20210628
DOI: 10.1086/651377
PMCID: PMC2838947

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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