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Article

The independent contribution of miRNAs to the missing heritability in CYP3A4/5 functionality and the metabolism of atorvastatin.

Scientific reports - 23 May 2016

Liu Ju-E, Ren Bin, Tang Lan, Tang Qian-Jie, Liu Xiao-Ying, Li Xin, Bai Xue, Zhong Wan-Ping, Meng Jin-Xiu, Lin Hao-Ming, Wu Hong, Chen Ji-Yan, Zhong Shi-Long

Abstract excerpt

To evaluate the independent contribution of miRNAs to the missing heritability in CYP3A4/5 functionality and atorvastatin metabolism, the relationships among three levels of factors, namely (1) clinical characteristics, CYP3A4/5 genotypes, and miRNAs, (2) CYP3A4 and CYP3A5 mRNAs, and (3) CYP3A activity, as well as their individual impacts on atorvastatin metabolism, were assessed in 55 human liver tissues....

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Identifiers

PMID: 27211076
DOI: 10.1038/srep26544
PMCID: PMC4876377

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Source receipt: pubmed, retrieved 7 Sept 2026.

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