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Article

Epigenetic Library Screen Identifies Abexinostat as Novel Regulator of Adipocytic and Osteoblastic Differentiation of Human Skeletal (Mesenchymal) Stem Cells.

Stem cells translational medicine - 1 Aug 2016

Ali Dalia, Hamam Rimi, Alfayez Musaed, Kassem Moustapha, Aldahmash Abdullah, Alajez Nehad M

Abstract excerpt

UNLABELLED: : The epigenetic mechanisms promoting lineage-specific commitment of human skeletal (mesenchymal or stromal) stem cells (hMSCs) into adipocytes or osteoblasts are still not fully understood. Herein, we performed an epigenetic library functional screen and identified several novel compounds, including abexinostat, which promoted adipocytic and osteoblastic differentiation of hMSCs. Using gene...

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Source

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Identifiers

PMID: 27194745
DOI: 10.5966/sctm.2015-0331
PMCID: PMC4954455

Genes

ALPL
FABP4
KLF15

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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