Article
Molecular pathology of head and neck cancer: implications for diagnosis, prognosis, and treatment.
Annual review of pathology - 1 Jan 2009
Pai Sara I, Westra William H
Abstract excerpt
The prototypic head and neck squamous cell carcinoma (HNSCC) arises from the mucosal lining of the upper aerodigestive tract, demonstrates squamous differentiation microscopically, involves older men with a long history of cigarette smoking and alcohol consumption, and is treated by multimodality therapy. HNSCC has long been regarded as a uniform disease process requiring a methodical and unwavering therapeutic...
Topics
- Age Factors
- Alcohol Drinking
- Biomarkers, Tumor
- Carcinoma, Squamous Cell
- Cell Transformation, Neoplastic
- Female
- Gene Expression Regulation, Neoplastic
- Genetic Predisposition to Disease
- Head and Neck Neoplasms
- Humans
- Male
- Papillomavirus Infections
- Patient Selection
- Phenotype
- Predictive Value of Tests
- Risk Factors
- Sex Factors
- Smoking