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Caspase-Independent Cell Death by Arsenic Trioxide in Human Cervical Cancer Cells

15 Dec 2004

Abstract excerpt

Although mechanisms of arsenic trioxide (As(2)O(3))-induced cell death have been studied extensively in hematologic cancers, those in solid cancers have yet to be clearly defined. In this study, we showed that the translocation of apoptosis-inducing factor (AIF) from mitochondria to the nucleus is required for As(2)O(3)-induced cell death in human cervical cancer cells. We also showed that reactive oxygen species...

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PMID: 15604259
DOI: 10.1158/0008-5472.can-04-1830

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