Article
Role of Plasmodium vivax Duffy-binding protein 1 in invasion of Duffy-null Africans.
Proceedings of the National Academy of Sciences of the United States of America - 31 May 2016
Gunalan Karthigayan, Lo Eugenia, Hostetler Jessica B, Yewhalaw Delenasaw, Mu Jianbing, Neafsey Daniel E, Yan Guiyun, Miller Louis H
Abstract excerpt
The ability of the malaria parasite Plasmodium vivax to invade erythrocytes is dependent on the expression of the Duffy blood group antigen on erythrocytes. Consequently, Africans who are null for the Duffy antigen are not susceptible to P. vivax infections. Recently, P. vivax infections in Duffy...
Topics
- Africa
- Animals
- Antigens, Protozoan
- DNA Copy Number Variations
- Duffy Blood-Group System
- Erythrocytes
- Humans
- Malaria, Vivax
- Mutation
- Plasmodium vivax
- Protein Binding
- Protozoan Proteins
- Real-Time Polymerase Chain Reaction
- Receptors, Cell Surface