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Article

Prevalence of somatic and germline mutations of Fumarate hydratase in uterine leiomyomas from young patients

29 Sept 2019

Abstract excerpt

AIMS: Hereditary leiomyomatosis and renal cell cancer (HLRCC) syndrome is caused by germline mutations in the Fumarate hydratase (FH) gene. In young women, the syndrome often presents with symptomatic uterine leiomyomas, leading to myomectomy or hysterectomy. In this study, we aimed to investigate the incidence and mutational profiles of FH-negative leiomyomas from young patients, thus allowing for early...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 31564060
DOI: 10.1111/his.14007

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