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Article

Functional evaluation of TERT-CLPTM1L genetic variants associated with susceptibility of papillary thyroid carcinoma.

Scientific reports - 17 May 2016

Ge Minghua, Shi Meng, An Changming, Yang Wenjun, Nie Xilin, Zhang Jian, Lv Zheng, Li Jinliang, Zhou Liqing, Du Zhongli, Yang Ming

Abstract excerpt

TERT is the catalytic subunit of telomerase which plays an essential part in cellular immortality by maintaining telomere integrity. TERT is commonly over-expressed in human malignancies, indicating its key role in cell transformation. The chromosome 5p15.33 TERT-CLPTM1L region has been associated with susceptibility of multiple cancers via a genome-wide association approach. However, the involvement of this...

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Source

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Identifiers

PMID: 27185198
DOI: 10.1038/srep26037
PMCID: PMC4869017

Genes

TERT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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