Article
The non-genomic loss of function of tumor suppressors: an essential role in the pathogenesis of chronic myeloid leukemia chronic phase.
BMC cancer - 16 May 2016
Crivellaro Sabrina, Carrà Giovanna, Panuzzo Cristina, Taulli Riccardo, Guerrasio Angelo, Saglio Giuseppe, Morotti Alessandro
Abstract excerpt
BACKGROUND: Chronic Myeloid Leukemia was always referred as a unique cancer due to the apparent independence from tumor suppressors' deletions/mutations in the early stages of the disease. However, it is now well documented that even genetically wild-type tumor suppressors can be involved in tumorigenesis, when functionally inactivated. In particular, tumor suppressors' functions can be impaired by subtle...
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