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Article

Molecular biology of chronic myeloid leukemia.

Cancer science - 1 Sept 2012

Maru Yoshiro

Abstract excerpt

Detailed information on the crystal structure of the pharmacologically targeted domains of the BCR-ABL molecule and on its intracellular signaling, which are potentially involved in growth, anti-apoptosis, metabolism and stemness, has made the study of chronic myeloid leukemia the most successful field in tumor biology. However, we now face the issue of drug resistance due to deregulation in the quality control...

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Topics

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Share to Fusion Proteins, bcr-abl
Share to Leukemia, Myelogenous, Chronic, BCR-ABL Positive
Share to Neoplastic Stem Cells

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Protein Conformation

Share to Protein Processing, Post-Translational

Share to Signal Transduction

Share to Tumor Microenvironment

Source

Open in PubMed Open full text

Identifiers

PMID: 22632137
DOI: 10.1111/j.1349-7006.2012.02346.x
PMCID: PMC7659193

Genes

BCR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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