Genome-wide Association Study of Idiopathic Osteonecrosis of the Femoral Head.

doi:10.1038/s41598-017-14778-y

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Article

Genome-wide Association Study of Idiopathic Osteonecrosis of the Femoral Head.

Scientific reports - 8 Nov 2017

Sakamoto Yuma, Yamamoto Takuaki, Sugano Nobuhiko, Takahashi Daisuke, Watanabe Toshiyuki, Atsumi Takashi, Nakamura Junichi, Hasegawa Yukiharu, Akashi Koichi, Narita Ichiei, Miyamoto Takeshi, Takeuchi Tsutomu, Ikari Katsunori, Amano Koichi, Fujie Atsuhiro, Kubo Toshikazu, Tada Yoshifumi, Kaneuji Ayumi, Nakamura Hiroaki, Miyamura Tomoya, Kabata Tamon, Yamaji Ken, Okawa Takahiro, Sudo Akihiro, Ohzono Kenji, Tanaka Yoshiya, Yasunaga Yuji, Matsuda Shuichi, Imai Yuuki, Akiyama Masato, Kubo Michiaki, Kamatani Yoichiro, Iwamoto Yukihide, Ikegawa Shiro

Abstract excerpt

Idiopathic osteonecrosis of the femoral head (IONFH) is an ischemic disorder that causes bone necrosis of the femoral head, resulting in hip joint dysfunction. IONFH is a polygenic disease and steroid and alcohol have already known to increase its risk; however, the mechanism of IONFH remains to be elucidated. We performed a genome-wide association study using ~60,000 subjects and found two novel loci on...

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PMID: 29118346
DOI: 10.1038/s41598-017-14778-y
PMCID: PMC5678103

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