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Article

Type II collagen gene variants and inherited osteonecrosis of the femoral head.

The New England journal of medicine - 2 Jun 2005

Liu Yu-Fen, Chen Wei-Ming, Lin Yung-Feng, Yang Ruei-Cheng, Lin Ming-Wei, Li Ling-Hui, Chang Ya-Hui, Jou Yuh-Shan, Lin Pei-Yu, Su Jih-Shyun, Huang Shiu-Feng, Hsiao Kwang-Jen, Fann Cathy S J, Hwang Hun-Way, Chen Yuan-Tsong, Tsai Shih-Feng

Abstract excerpt

BACKGROUND: Avascular necrosis of the femoral head (ANFH) causes disability that often requires surgical intervention. Most cases of ANFH are sporadic, but we identified three families in which there was autosomal dominant inheritance of the disease and mapped the chromosomal position of the gene to 12q13. METHODS: We carried out haplotype analysis in the families, selected candidate genes from the critical...

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Share to Chromosomes, Human, Pair 12
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 15930420
DOI: 10.1056/NEJMoa042480

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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