Resolving the Conflict Between Associative Overdominance and Background Selection.

doi:10.1534/genetics.116.188912

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Article

Resolving the Conflict Between Associative Overdominance and Background Selection.

Genetics - 1 Jul 2016

Zhao Lei, Charlesworth Brian

Abstract excerpt

In small populations, genetic linkage between a polymorphic neutral locus and loci subject to selection, either against partially recessive mutations or in favor of heterozygotes, may result in an apparent selective advantage to heterozygotes at the neutral locus (associative overdominance) and a retardation of the rate of loss of variability by genetic drift at this locus. In large populations, selection against...

Topics

Computer Simulation
Genetic Drift
Genetic Linkage
Genetics, Population
Heterozygote
Models, Genetic
Mutation
Population Density
Recombination, Genetic
Selection, Genetic

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Identifiers

PMID: 27182952
DOI: 10.1534/genetics.116.188912
PMCID: PMC4937488

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