Article
Re-emergence of methicillin susceptibility in a resistant lineage of Staphylococcus aureus.
The Journal of antimicrobial chemotherapy - 1 May 2017
Ledda Alice, Price James R, Cole Kevin, Llewelyn Martin J, Kearns Angela M, Crook Derrick W, Paul John, Didelot Xavier
Abstract excerpt
Objectives: MRSA is a leading cause of hospital-associated infection. Acquired resistance is encoded by the mecA gene or its homologue mecC , but little is known about the evolutionary dynamics involved in gain and loss of resistance. The objective of this study was to obtain an expanded understanding of Staphylococcus aureus methicillin resistance microevolution in vivo , by focusing on a single lineage....
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