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Article

BCR-ABL-specific CD4+ T-helper cells promote the priming of antigen-specific cytotoxic T cells via dendritic cells.

Cellular & molecular immunology - 1 Jan 2018

Ueda Norihiro, Zhang Rong, Tatsumi Minako, Liu Tian-Yi, Kitayama Shuichi, Yasui Yutaka, Sugai Shiori, Iwama Tatsuaki, Senju Satoru, Okada Seiji, Nakatsura Tetsuya, Kuzushima Kiyotaka, Kiyoi Hitoshi, Naoe Tomoki, Kaneko Shin, Uemura Yasushi

Abstract excerpt

The advent of tyrosine kinase inhibitor (TKI) therapy markedly improved the outcome of patients with chronic-phase chronic myeloid leukemia (CML). However, the poor prognosis of patients with advanced-phase CML and the lifelong dependency on TKIs are remaining challenges; therefore, an effective therapeutic has been sought. The BCR-ABL p210 fusion protein's junction region represents a leukemia-specific...

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Identifiers

PMID: 27181332
DOI: 10.1038/cmi.2016.7
PMCID: PMC5827172

Genes

BCR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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