Childhood gene-environment interactions and age-dependent effects of genetic variants associated with refractive error and myopia: The CREAM Consortium.

doi:10.1038/srep25853

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Article

Childhood gene-environment interactions and age-dependent effects of genetic variants associated with refractive error and myopia: The CREAM Consortium.

Scientific reports - 13 May 2016

Fan Qiao, Guo Xiaobo, Tideman J Willem L, Williams Katie M, Yazar Seyhan, Hosseini S Mohsen, Howe Laura D, Pourcain Beaté St, Evans David M, Timpson Nicholas J, McMahon George, Hysi Pirro G, Krapohl Eva, Wang Ya Xing, Jonas Jost B, Baird Paul Nigel, Wang Jie Jin, Cheng Ching-Yu, Teo Yik-Ying, Wong Tien-Yin, Ding Xiaohu, Wojciechowski Robert, Young Terri L, Pärssinen Olavi, Oexle Konrad, Pfeiffer Norbert, Bailey-Wilson Joan E, Paterson Andrew D, Klaver Caroline C W, Plomin Robert, Hammond Christopher J, Mackey David A, He Mingguang, Saw Seang-Mei, Williams Cathy, Guggenheim Jeremy A

Abstract excerpt

Myopia, currently at epidemic levels in East Asia, is a leading cause of untreatable visual impairment. Genome-wide association studies (GWAS) in adults have identified 39 loci associated with refractive error and myopia. Here, the age-of-onset of association between genetic variants at these 39 loci and refractive error was investigated in 5200 children assessed longitudinally across ages 7-15 years, along with...

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PMID: 27174397
DOI: 10.1038/srep25853
PMCID: PMC4865831

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ZMAT4

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