Article
Assessment of trichloroethylene (TCE) exposure in murine strains genetically-prone and non-prone to develop autoimmune disease.
Journal of environmental science and health. Part A, Toxic/hazardous substances & environmental engineering - 1 Apr 2009
Keil Deborah E, Peden-Adams Margie M, Wallace Stacy, Ruiz Phillip, Gilkeson Gary S
Abstract excerpt
There is increasing laboratory and epidemiologic evidence relating exposure to trichloroethylene (TCE) with autoimmune disease including scleroderma and lupus. New Zealand Black/New Zealand White (NZBWF1) and B6C3F1 mice were exposed to TCE (0, 1, 400 or 14,000 ppb) via drinking water for 27 or 30 weeks, respectively. NZBWF1 mice spontaneously develop autoimmune disease while B6C3F1 mice, a standard strain used...
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