Article
In Silico Investigation of Traditional Chinese Medicine for Potential Lead Compounds as SPG7 Inhibitors against Coronary Artery Disease.
Molecules (Basel, Switzerland) - 5 May 2016
Chen Kuen-Bao, Chen Kuan-Chung, Chang Ya-Lin, Chang Kun-Lung, Chang Pei-Chun, Chang Tung-Ti, Chen Yu-Chian
Abstract excerpt
Coronary artery disease (CAD) is the most common cause of heart attack and the leading cause of mortality in the world. It is associated with mitochondrial dysfunction and increased level of reactive oxygen species production. According to the Ottawa Heart Genomics Study genome-wide association study, a recent research identified that Q688 spastic paraplegia 7 (SPG7) variant is associated with CAD as it bypasses...
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