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Article

CD82 palmitoylation site mutations at Cys5+Cys74 affect EGFR internalization and metabolism through recycling pathway.

Acta biochimica et biophysica Sinica - 25 Mar 2022

Bu Jingya, Zhong Weiliang, Li Meixian, He Shuiqing, Zhang Mingzhe, Zhang Yu, Li Ying

Abstract excerpt

Tetraspanin CD82 often participates in regulating the function of epidermal growth factor receptor (EGFR) and hepatocyte growth factor receptor (c-Met). Palmitoylation is a post-translational modification that contributes to tetraspanin web formation and affects tetraspanin-dependent cell signaling. However, the molecular mechanisms by which CD82 palmitoylation affects the localization and stability of EGFR and...

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PMID: 35538033
DOI: 10.3724/abbs.2022011
PMCID: PMC9828285

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