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The TatD-like DNase of Plasmodium is a virulence factor and a potential malaria vaccine candidate

6 May 2016

Abstract excerpt

Neutrophil extracellular traps (NETs), composed primarily of DNA and proteases, are released from activated neutrophils and contribute to the innate immune response by capturing pathogens. Plasmodium falciparum, the causative agent of severe malaria, thrives in its host by counteracting immune elimination. Here, we report the discovery of a novel virulence factor of P. falciparum, a TatD-like DNase (PfTatD) that...

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PMID: 27151551
DOI: 10.1038/ncomms11537

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