Article
Rebiopsy for patients with non-small-cell lung cancer after epidermal growth factor receptor-tyrosine kinase inhibitor failure.
Cancer science - 1 Jul 2016
Kawamura Takahisa, Kenmotsu Hirotsugu, Taira Tetsuhiko, Omori Shota, Nakashima Kazuhisa, Wakuda Kazushige, Ono Akira, Naito Tateaki, Murakami Haruyasu, Mori Keita, Nakajima Takashi, Ohde Yasuhisa, Endo Masahiro, Takahashi Toshiaki
Abstract excerpt
Although third-generation epidermal growth factor receptor-tyrosine kinase inhibitors (EGFR-TKI) can overcome T790M-mediated resistance in non-small-cell lung cancer (NSCLC), rebiopsy to confirm T790M status is occasionally difficult. We aimed to investigate the current tendency and the limitations of rebiopsy in clinical practice. This study included 139 consecutive NSCLC patients with EGFR mutations, who had...
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