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Article

A Silenced vanA Gene Cluster on a Transferable Plasmid Caused an Outbreak of Vancomycin-Variable Enterococci.

Antimicrobial agents and chemotherapy - 1 Jul 2016

Sivertsen Audun, Pedersen Torunn, Larssen Kjersti Wik, Bergh Kåre, Rønning Torunn Gresdal, Radtke Andreas, Hegstad Kristin

Abstract excerpt

We report an outbreak of vancomycin-variable vanA(+) enterococci (VVE) able to escape phenotypic detection by current guidelines and demonstrate the molecular mechanisms for in vivo switching into vancomycin resistance and horizontal spread of the vanA cluster. Forty-eight vanA(+) Enterococcus faecium isolates and one Enterococcus faecalis isolate were analyzed for clonality with pulsed-field gel electrophoresis...

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Identifiers

PMID: 27139479
DOI: 10.1128/AAC.00286-16
PMCID: PMC4914660

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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