Intensified vmPFC surveillance over PTSS under perturbed microRNA-608/AChE interaction.

doi:10.1038/tp.2016.70

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Article

Intensified vmPFC surveillance over PTSS under perturbed microRNA-608/AChE interaction.

Translational psychiatry - 3 May 2016

Lin T, Simchovitz A, Shenhar-Tsarfaty S, Vaisvaser S, Admon R, Hanin G, Hanan M, Kliper E, Bar-Haim Y, Shomron N, Fernandez G, Lubin G, Fruchter E, Hendler T, Soreq H

Abstract excerpt

Trauma causes variable risk of posttraumatic stress symptoms (PTSS) owing to yet-unknown genome-neuronal interactions. Here, we report co-intensified amygdala and ventromedial prefrontal cortex (vmPFC) emotional responses that may overcome PTSS in individuals with the single-nucleotide polymorphism (SNP) rs17228616 in the acetylcholinesterase (AChE) gene. We have recently shown that in individuals with the minor...

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PMID: 27138800
DOI: 10.1038/tp.2016.70
PMCID: PMC5070052

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