Article
Plasmin is a natural trigger for bradykinin production in patients with hereditary angioedema with factor XII mutations.
The Journal of allergy and clinical immunology - 1 Nov 2016
de Maat Steven, Björkqvist Jenny, Suffritti Chiara, Wiesenekker Chantal P, Nagtegaal Willem, Koekman Arnold, van Dooremalen Sanne, Pasterkamp Gerard, de Groot Philip G, Cicardi Marco, Renné Thomas, Maas Coen
Abstract excerpt
BACKGROUND: Patients with angioedema experience unpredictable attacks of tissue swelling in which bradykinin is implicated. Several distinct mutations in Factor XII (FXII) are associated with hereditary angioedema (HAE) in the presence of normal C1 esterase inhibitor activity (FXII-HAE). The underlying disease mechanisms are unclear, which complicates diagnosis and treatment. OBJECTIVE: We sought to identify the...
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