Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

MicroRNA-127-5p regulates osteopontin expression and osteopontin-mediated proliferation of human chondrocytes.

Scientific reports - 29 Apr 2016

Tu Min, Li Yusheng, Zeng Chao, Deng Zhenhan, Gao Shuguang, Xiao Wenfeng, Luo Wei, Jiang Wei, Li Liangjun, Lei Guanghua

Abstract excerpt

The aim of this study was to determine the specific microRNA (miRNA) that regulates expression of osteopontin (OPN) in osteoarthritis (OA). The potential regulatory miRNAs for OPN messenger RNA (mRNA) were predicted by miRNA prediction programs. Among eight potential regulatory miRNAs, miR-220b, miR-513a-3p and miR-548n increased, while miR-181a, miR-181b, miR-181c, miR-181d and miR-127-5p decreased in OA...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to 3' Untranslated Regions
Share to Binding Sites

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Cell Proliferation

Share to Chondrocytes

Share to Down-Regulation

Share to MicroRNAs

Share to Osteoarthritis

Share to Osteopontin

Source

Open in PubMed Open full text

Identifiers

PMID: 27126955
DOI: 10.1038/srep25032
PMCID: PMC4850404

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

MicroRNA-127-5p regulates osteopontin expression and osteopontin-mediated proliferation of human chondrocytes.PMID 27126955Read ↗

MicroRNAs’ Involvement in Osteoarthritis and the Prospects for TreatmentsSemantic proximity Read ↗

Long noncoding RNA LINC00461 induced osteoarthritis progression by inhibiting miR-30a-5pSemantic proximity Read ↗

Role of MicroRNA in OsteoarthritisSemantic proximity Read ↗

Positive Feedback Loop LINC00511/miR-150-5p/SP1 Modulates Chondrocyte Apoptosis and Proliferation in OsteoarthritisSemantic proximity Read ↗

MicroRNA in OsteoarthritisSemantic proximity Read ↗

Circulating miR-126-3p is a mechanistic biomarker for knee osteoarthritisSemantic proximity Read ↗

miR‑146a‑5p expression is upregulated by the CXCR4 antagonist TN14003 and attenuates SDF‑1‑induced cartilage degradationSemantic proximity Read ↗

MicroRNA-15a-5p Regulates the Development of Osteoarthritis by Targeting PTHrP in ChondrocytesSemantic proximity Read ↗

The Interaction between microRNAs and the Wnt/β-Catenin Signaling Pathway in OsteoarthritisSemantic proximity Read ↗

Regulation of the IGFBP-5 and MMP-13 genes by the microRNAs miR-140 and miR-27a in human osteoarthritic chondrocytesSemantic proximity Read ↗

MicroRNA-21 controls the development of osteoarthritis by targeting GDF-5 in chondrocytesSemantic proximity Read ↗

Circulating miR-126-3p is a mechanistic biomarker for knee osteoarthritisSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.