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Article

Synergistic effects of c-Jun and SP1 in the promotion of TGFβ1-mediated diabetic nephropathy progression.

Experimental and molecular pathology - 1 Jun 2016

Gao Pan, Wei Yingze, Zhang Zhigang, Zeng Wenjiao, Sun Daming, Liu Danyang, Hou Bo, Zhang Congying, Zhang Nong, Li Hui, Li Liliang

Abstract excerpt

Diabetic nephropathy (DN) is a major complication of diabetes mellitus. Transforming growth factor beta 1 (TGFβ1) is a well-distinguished mediator of progressive renal fibrosis in DN. However, the molecular mechanisms contributing to enhanced TGFβ1 expression in the progression of DN are not fully understood. Herein, we reported that c-Jun and specificity protein 1 (SP1) were critical upstream regulators of TGFβ1...

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Identifiers

PMID: 27112839
DOI: 10.1016/j.yexmp.2016.04.005

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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