Article
Enhanced secretion of recombinant proteins via signal recognition particle (SRP)-dependent secretion pathway by deletion of rrsE in Escherichia coli.
Biotechnology and bioengineering - 1 Nov 2016
Lee Yong Jae, Lee Roojin, Lee Se Hwa, Yim Sung Sun, Jeong Ki Jun
Abstract excerpt
Although signal recognition particle (SRP)-dependent secretion pathway, which is characterized by co-translational translocation, helps prevent cytoplasmic aggregation of proteins before secretion, its limited capacity for the protein secretion is a major hurdle for utilizing the pathway as an attractive route for secretory production of recombinant proteins. Therefore, we developed an Escherichia coli mutant,...
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