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Article

Neutralizing inhibitors in the airways of naïve ferrets do not play a major role in modulating the virulence of H3 subtype influenza A viruses.

Virology - 1 Jul 2016

Job Emma R, Pizzolla Angela, Nebl Thomas, Short Kirsty R, Deng Yi-Mo, Carolan Louise, Laurie Karen L, Brooks Andrew G, Reading Patrick C

Abstract excerpt

Many insights regarding the pathogenesis of human influenza A virus (IAV) infections have come from studies in mice and ferrets. Surfactant protein (SP)-D is the major neutralizing inhibitor of IAV in mouse airway fluids and SP-D-resistant IAV mutants show enhanced virus replication and virulence in mice. Herein, we demonstrate that sialylated glycoproteins, rather than SP-D, represent the major neutralizing...

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Source

Identifiers

PMID: 27110707
DOI: 10.1016/j.virol.2016.01.024

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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