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Article

Protection afforded by intranasal immunization with the neuraminidase-lacking mutant of influenza A virus in a ferret model.

Vaccine - 22 Apr 2005

Mishin Vasiliy P, Nedyalkova Marina S, Hayden Frederick G, Gubareva Larisa V

Abstract excerpt

Protective efficacy of the intranasal immunization with the neuraminidase (NA)-deficient mutant of the influenza A virus was investigated in ferrets. Despite the highly attenuated replication in vivo, the mutant completely protected the animals against the wild type virus challenge. When challenge was done with antigenic drift variants, significant reductions in the viral titers, inflammatory cell counts, and...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 15780741
DOI: 10.1016/j.vaccine.2004.11.058

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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