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Article

Genetic association, mRNA and protein expression analysis identify ATG4C as a susceptibility gene for Kashin-Beck disease.

Osteoarthritis and cartilage - 1 Feb 2017

Wu C, Wen Y, Guo X, Yang T, Shen H, Chen X, Tian Q, Tan L, Deng H-W, Zhang F

Abstract excerpt

OBJECTIVE: Recent study observed defective autophagy in chondrocytes with Kashin-Beck Disease (KBD). To clarify the potential role of autophagy-related ATG4C gene in the development of KBD, we conducted an integrative analysis of genetic association, messenger ribonucleic acid (mRNA) and protein expression of ATG4C in KBD patients. METHODS: 1026 subjects (559 KBD patients and 467 healthy cases) were enrolled in...

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Identifiers

PMID: 27742532
DOI: 10.1016/j.joca.2016.09.019

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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