Article
DNA Methylation and Mutation of Small Colonic Neoplasms in Ulcerative Colitis and Crohn's Colitis: Implications for Surveillance.
Inflammatory bowel diseases - 1 Jul 2016
Johnson David H, Taylor William R, Aboelsoud Mohammed M, Foote Patrick H, Yab Tracy C, Cao Xiaoming, Smyrk Thomas C, Loftus Edward V, Mahoney Douglas W, Ahlquist David A, Kisiel John B
Abstract excerpt
BACKGROUND: Stool DNA testing in patients with inflammatory bowel disease (IBD) may detect colorectal cancer and advanced precancers with high sensitivity; less is known about the presence of DNA markers in small IBD lesions, their association with metachronous neoplasia, or contribution to stool test positivity. METHODS: At a single center in 2 blinded phases, we assayed methylated bone morphogenic protein 3,...
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